Several. Kingdom Come their child grows up with cosmic power and joins the Quintessence, in another Elseworlds all super-beings were stripped of their powers and after Lois left him he ended up with Wonder Woman and had a child who was shown as a baby at the end supposedly heralding the next stage of evolution with powers vaster than those humanity had already seen from the likes of them.
Yet another terrible wars killed off all humans, leaving only the depowered superhumans beind. Unfortunately while they originally all worked together in piece Captain Marvel's jealous desire had him repeatedly calling forth to Shazam for power, which eventually started everyone having powers again. Sides formed up and the unnatural magic caused the world to come to an end. The only survivor was Superman's child by Wonder Woman which he launched into space using the power ring of Green Lantern, which he also sent off with him in hopes on whatever new world he found he might save it before it got to where Earth did.
"A shared universe, like any fictional construct, hinges on suspension of disbelief. When continuity is tossed away, it tatters the construct. Undermines it."
-- Peter David
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